Catheter occlusions are costly and cause serious problems for caregivers and their patients.  25% of central line catheters develop an intraluminal thrombotic partial or fully occlusion. Learn how our TKO technology has been proven to provide Blood Reflux Protection 24/7!™  for all of your Peripheral, PICC and CVC Catheters.            
Designed To Prevent Occlusions
The Nexus TKO® (“To Keep Open”) Anti-Reflux technology is designed to deliver I.V. Catheter Patency 24/7!™
TKO reduces potential delays in delivering IV therapy TKO reduces unscheduled I.V. catheter restarts TKO minimizes trauma to the patient TKO has been proven to reduce occlusions and tPA by up to 85% 
Blood Reflux Protection 24/7!™ You deserve a partner at both ends of your catheter!
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Products & Solutions Infusion Therapy Nexus TKO® (To Keep Open) Nexus NIS® (Nexus Injection Site)
Catheter Occlusions create clinically and financially challenges
“Theoretically, Blood Reflux into either the IV catheter or the needleless connector increases both the risk of occlusion and biofilm formation.” William R. Jarvis MD
1. Timisit JF, Missett b, Carlet J, et al. Central vein catheter-related thrombosis in intensive care patients, risk factors, and relationships with catheter-related sepsis. Chest. 1998:114(1):207-213. 2. Mehall JR, Saltzman DA, Jackson RJ, Smith SD, Fibrin sheath enhances central venous infection. Critical Care Med. 202:30(4); 908-912. 3. Raad II, Luna M, Khalil SM, Costerton JW, Lam C, Bodey  GP, 4. Nakazama N. Infectious and thrombotic complications of central venous catheters. Semin Oncology Nurse, 2010:26(2) 121-131. 5. Lordick F, Hentrich M, Decker T, et al, Ultrasound screening for internal jugular vein thrombosis aids the detection of central venous catheter-related infections in patients with haemato-oncological diseases: a prospective observational study. Br J Haematol 2003;120:1073-1078. 6. Moureau N, Catheter-related infections and thrombosis: A proven relationship, Arrow, Teleflex, White Paper 2013,  7.Jasinsky RN BSN, J Wurster RN MSN, “Occlusions Reduction and Heparin Elimination Trial using an Anti-Reflux Device on Peripheral and Central Intravenous Lines”, Intravenous Nurses Society  8.  S Mitch RN CRNI, B Brandmeyer RN BSN, “PICC and Midline Catheter Occlusion Rates:  A Prospective Study Comparing the Interlink Split Septum Device versus Nexus TKO Split Septum Pressure Activated Anti-Reflux Diaphragm”. 9. GLP-Study, Nexus TKO®, 96-Activation Microbial Barrier Performance Study, on file at Nexus Medical LLC, 10. Lab results on file at Nexus Medical, LLC, 11. Jarvis,W.  Choosing the best design for the Intravenous needleless connection to prevent HA-BSI’s.  Infection Control Today, 2010 Aug. 13. Hadaway L. Reopen the pipeline for IV therapy. Nursing. 2005; 35(8):54-61. 14. O’Grady NP, Alexander M, Dellinger EP, et al. Guidelines for the prevention of intravascular catheter-related infections. MMWR Recomm Rep. 2002;51(RR-10):1-26. 15. Haire WD, Atkinson JB, Stephen LC, Kotulak GD, et al. Urokinase versus recombinant tissue plasminogen activator in thrombosed central venous catheters: a double- blinded, randomized trial. Thromb Haemost. 1994;72(4):543-7. 16. Deitcher S, et al. Safety and efficacy of alteplase for restoring function in occluded central venous catheters: results of the cardiovascular thrombolytic to open occluded lines trial. J Clin Oncol. 2002;20(1): 317-24. 17.  Timoney JP, Malkin MG, Leone DM, Groeger JS, Heaney ML, Keefe DL, Klang M, Lucarelli CD, Muller RJ, Eng SL, Connor M, Small TN, Brown AE, Saltz LB. Safe and cost effective use of alteplase for the clearance of occluded central venous access devices, JCO. Apr 1, 2002:1918-1922; DOI:10.1200/JCO.2002.07.131. 18. Ponec D, Irwin D, Haire WD, Hill PA, Li X, McCluskey ER; COOL Investigators. Recombinant tissue plasminogen activator (alteplase) for restoration of flow in occluded central venous access devices: a double-blind placebo-controlled trial—the Cardiovascular Thrombolytic to Open Occluded Lines (COOL) efficacy trial. J Vasc Interv Radiol. 2001 Aug;12(8):951-5. 19. Maki DG, Kluger DM, Crnich CJ.  The risk of bloodstream infection in adults with different intravascular devices: a systematic review of 200 published prospective studies.  Mayo Clin Proc 2006; 81:1159-71.  20.  US Department of Health & Human Services, CMS Centers for Medicare & Medicaid Services. Hospital-acquired conditions (present on admission indicator). Accessed January 10, 2008. 21. Ryder, M. Catheter-related infections: It’s all about biofilm. Topics Adv. Practice of Nursing Journal.2005 5(3)
Nexus TKO®-6 is your proven Solution in providing IV Catheter Patency 24/7!™
Nexus TKO® Clinical Evidence
Catheter occlusions are difficult to avoid and create unwanted complications
25% of all central venous catheter (CVC) develop partial or full occlusions17,18 Blood can inadvertently reflux into a catheter in multiple ways Current needle free injection sites do not effectively address the many causes of blood reflux Blood reflux may lead to several unintended IV complications, including the following: o occlusions o infiltrations o phlebitis o costly catheter restarts o catheter-related bloodstream infections (CRBSIs) Occlusions  may result in delayed therapy,13 Occlusions increases the risk of CRBSI’s, 1,2,3,4,17,18 Occlusions created the need for catheter replacement or exchange, 13 Occlusions prevent blood sample from CVC/PICC catheter13 When blood refluxes into a catheter, there is the potential for clinicians to force the syringe plunger forward when flushing and damage the intima of the vein wall which may end in an IV complication which resembles an IV infiltration 10 Clotted Catheters are known contributors to catheter-related bloodstream infections (CRBSIs)1,2,3,4, 87% percentage of all bloodstream infections involve some type of IV device21 Catheter occlusions  lead to catheter replacement, increased risk of complications, added patient stress and risk of infection13 CRBSIs are the most costly and life threatening of all healthcare-acquired infections13 CRBSIs cost up to $35,000 per episode, with more than 250,000-500,000 episodes per year in the US13 “Centers for Medicare and Medicaid Services (CMS) no longer reimburse hospitals for vascular catheter- associated infections (initiated October 2008)”20
Partial, Intraluminal Thrombotic Catheter Occlusion
Catheter occlusions are difficult to avoid and create unwanted complications
Partial, Intraluminal Thrombotic Catheter Occlusion
How The TKO Anti-Reflux Diaphragm Works to Prevent Occlusions
Nexus TKO®-6 Anti-Reflux Technology Provides Blood Reflux Protection 24/7!™ The Nexus TKO®-6 Anti-Reflux diaphragm automatically opens and closes based upon fluid pressure.  The TKO diaphragm open towards the patient when fluid pressure from sources such as IV pump, syringe pump, IV bag, flushing or medication syringe are used.  When the fluid pressure drops the TKO diaphragm instantly and automatically closes prevention blood reflux into the catheters.
No clamping sequence required: The Nexus TKO® Anti-Reflux technology requires  NO CHANGE in practice or clamping sequence, the device automatically provides                        Blood Reflux Protection 24/7!
Bi-Directional Flow Control 24/7!™ DOME SHAPED TKO™ Diaphragm Single Piece-Crystal Clear 3-Position
Infusion Flow Rate at 40 inches 4500mL/Hour
Normally Closed Position: The TKO Diaphragm provides Blood Reflux Protection 24/7™!
Flush/Infusion: The TKO Diaphragm opens forward with normal gravity pressure
Blood Sampling/Patency Check: The TKO Diaphragm opens in reverse for safe and easy blood sampling
Opening Pressure
15mmHg 0.3 psi
Aspiration Pressure
300mmHg 6.0 psi
Nexus TKO® is your proven Solution in providing IV Catheter Patency 24/7!™
Nexus TKO™ is NOT Negative, Positive or Neutral displacement. It’s a NEW Technology Solution which is designed to automatically deliver “IV Catheter Patency 24/7™”! Older traditional needle free technology such as Negative, Positive and Neutral displacement devices are not designed to protect your patient from Blood Reflux 24-hour a day 7-days a week!   These older designs are incapable of providing the instant and automatic feature and benefit of Bi-Directional Flow Control 24/7! ™  The older more traditional technologies (negative, positive & neutral displacement) were designed only to protect against needle stick injuries rather than provide IV Catheter Patency 24/7!™ The older traditional needle free connector technologies claimed “Saline Only” but have no clinical evidence they eliminate costly tPA while eliminating heparin flushing practice. The older traditional needle free connector technologies are not designed to provide the necessary clinical and economic value required for hospitals to conform to the “Affordable Care Act” and the related “Accountable Care Organization”.
Nexus TKO-6P Anti-Reflux Technology
“The design of your needle free connector plays a substantial role in your ability to limit hospital-acquired bloodstream infections (HA-BSA).11” William R. Jarvis MD
Solutions > Infusion Therapy > Designed To Prevent Occlusions